From the publisher's website:

In the Operation game, you get to be the doctor and make Cavity Sam better or get the buzzer! Cure him of all his wacky ailments like headphone headache and gamer's thumb by picking funny ailment pieces out of the game tray with a pair of tweezers. But watch out! If you touch the sides of the openings, you'll get the buzzer and light up Cavity Sam's nose! The player who removes the most ailments wins! Be the doctor, and take turns using the tweezers to carefully remove 11 easy-grab ailments from large openings in the game tray. Be careful! Touch the side of an opening, and you'll hear the buzzer and Cavity Sam's nose will light up. Players take turns trying to remove wacky ailments like headphone headache, gamer's thumb, a cranky knee and frostbite. The player who successfully removes the most ailments from Cavity Sam is the winner!